When fall of Constantinople fell to the ottoman turks in 1453, scholars fled to rome with ancient greek manuscripts.
Historically, any document that has been written by hand or typewritten when practical typewriters were accessible, as opposed to being mechanically printed or indirectly or automatically duplicated, was referred to as a manuscript (shortened MS for singular and MSS for plural).
As opposed to its presentation as a printed version of the same, the term has more recently come to be understood to include cover any written, typed, or term copy of an author's work. All texts and books were manuscripts prior to the invention of printing. Manuscripts are not characterized by their content, which may include words along with explanatory graphics, mathematics, maps, music notation, or pictures.
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