1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Vadim26 [7]
1 year ago
13

dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of parkinson's disease

Biology
1 answer:
Triss [41]1 year ago
3 0

Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.

We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.

Learn more about Parkinson's disease brainly.com/question/28169444

#SPJ4

You might be interested in
Re-arrange these pictures and put them in chronological order?
TiliK225 [7]
Bacteria 
Amphibians
Reptiles
Mammals
6 0
3 years ago
Read 2 more answers
Which type of rock forms only from the solidification of magma?
bixtya [17]

Answer:

igneous rock

Explanation:

Look at the chart metamorphic rock melts turning into magma magma solidifies into IGNEOUS ROCK

3 0
3 years ago
Abnormal development or growth, especially of cells, is known as
Nady [450]

Answer:

Dysplasia

Explanation:

4 0
2 years ago
Why is it impossible for male calico cats to exist
Kisachek [45]

Answer:

genetics

Explanation:

calico cats must also inherit a gene unrelated to the X and Y chromosomes that codes for white fur. Because male cats have one X chromosome with code for black or orange and one Y chromosome with no color genes, they cannot technically be calico. About one in every 3,000 calico cats is born a male, and, unfortunately, don't live as long as female calicos due to their genetic abnormalities. XXY Syndrome renders male calicos sterile and can be the root cause of many other health problems

8 0
3 years ago
The normal shape of an enzyme is as shown in structure A. If the enzyme's shape changes to that shown in structure B, what are t
Varvara68 [4.7K]

Answer:

There is no image showing the shape of an enzyme, however, the question can still be answered based on basic understanding. The answers are;

- Less binding of substrate

- won't follow the lock-and-key pattern of enzyme binding

Explanation:

An enzyme is a biological catalyst that regulates the rate of chemical reactions in living systems. Enzymes are proteinous in nature and every protein is made up of an amino acid sequence. The amino acid sequence forms a three-dimensional shape that determines the functionality of the enzyme.

Enzymes catalyze reactions by binding to their substrates in a lock and key pattern. This makes enzymes substrate-specific. If the enzyme's normal shape changes, the following will occur:

- Less binding of substrate

- won't follow the lock-and-key pattern of enzyme binding.

8 0
3 years ago
Other questions:
  • Many organisms depend on the land as a food source. Seasons can affect the amount of food that is available to these organisms.
    14·1 answer
  • Why type of molecules is fat?<br> A)protein <br> B)lipid <br> C)nucleic acid <br> D)carbohydrate
    12·2 answers
  • Why do increased temperatures decrease photosystem II activity?
    12·1 answer
  • Which of the following explains why children must be vaccinated for communicable diseases, like measles?
    10·2 answers
  • You are evaluating a 5-year-old admitted to shadow general hospital with asthma having an acute exacerbation. what would you exp
    7·2 answers
  • Which of these are a behavioral adaption in wolves
    15·2 answers
  • Macromolecules are made of smaller subunits called monomers. These large molecules are also broken down into their respective mo
    10·1 answer
  • What is TRUE about the relationship between cells and the organism that they are a part of?
    13·2 answers
  • Carbon dioxide-rich blood is received from the body in the right ventricle.<br> True<br> False
    9·2 answers
  • Please help! Thank you! :)
    8·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!