1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Vadim26 [7]
2 years ago
13

dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of parkinson's disease

Biology
1 answer:
Triss [41]2 years ago
3 0

Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.

We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.

Learn more about Parkinson's disease brainly.com/question/28169444

#SPJ4

You might be interested in
Air is.....
GREYUIT [131]

Answer:

C- homogeneous mixture

Explanation:

its made up of multiple elements that aren't chemically combined.

you cannot see the parts of the mixture

6 0
2 years ago
Alcoholic fermentation
Gala2k [10]

A) Forms fewer ATP molecules than cellular respiration.  

It usually forms 2ATP as opposed to 38ATP formed during cellular respiration.

8 0
3 years ago
Read 2 more answers
When does the zygote attach to the uterine wall?
Fynjy0 [20]
About 11 to 15 days after conception the zygote attach to the uterine wall
6 0
3 years ago
What are the products of photosynthesis
Lynna [10]

Answer:

glucose and oxygen

Explanation:

6 0
3 years ago
Can someone tell me what species this butterfly
valentina_108 [34]
This is a monarchy butterfly
3 0
3 years ago
Read 2 more answers
Other questions:
  • Which question is most likely to be found in a dichotomous key for fish identification?
    13·1 answer
  • The cells of your body are mostly made of?
    13·2 answers
  • which taxonomic group do the organisms in the diagram fall underA fungi since they lack a cell wall and nucleus be protists sinc
    13·1 answer
  • Kevin has a very detailed model of the solar system where each planet is made out of granite rock. Since his little sister reall
    7·2 answers
  • Help pls it would be nice :p
    5·2 answers
  • Describe the function of macromolecules
    9·2 answers
  • What process does a multi-cellular organism use to replace its damaged body cells
    14·2 answers
  • Explain three ways in which the abiotic components in your area that affect the biotic components.
    13·1 answer
  • Define Scientific method ?​
    8·2 answers
  • Which tides are the highest?
    6·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!