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Law Incorporation [45]
1 year ago
12

Explain why the deletion or inactivation of the SH3 domain in Src would have an oncogenic effect while the mutation of Tyr 416 t

o Phe would not.
Biology
1 answer:
Readme [11.4K]1 year ago
7 0

The SH3 (SRC homology 3 ) domain in Src involved in various functions as regulation of cell cycle activities ( like cell proliferation and differentiation , survival ,migration and cytoskeletal modifications ) but Tyr 416 does not .

Hence the deletion or inactivation of the SH3 domain in Src would have an oncogenic effect while the mutation of Tyr 416 to phe would not.

<h3>What is SH3 domain ?</h3>

SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids .it is a small protein domain of about 60 amino acid residues  .

<h3>What is oncogenic effect ?</h3>

If through mutation ,normal genes are up-regulated ( gain -of-function mutation ) ,they will predispose the cell to cancer ;these type of genes are called as oncogenes and their effect is called as oncogenic effect.

usually multiple oncogenes ,along with mutated apoptotic or tumor suppressor genes will all act in concert to cause cancer .

Learn more about cancer  here:

brainly.com/question/26059802

#SPJ4

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If thymidine dimers created by UV irradiation persist until DNA replication, DNA polymerase is likely to make a mistake reading
marishachu [46]

Answer:

Thymidine dimers is likely to be repair as soon as it is originated but if left unrepaired then it causes  frame shift mutations.

Explanation:

In case of Bacterium if UV irradiation induces covalent linkage of two thymidine present adjacently to each other or on a single strand to make thymidine dimers.

These either excised via DNA repair enzyme like Endonuclease V and the proof reading activity of DNA polymerase I enzyme help in incorporation of nucleotide by taking the unmutated original strand as a template.

These dimers if not excised before second round of replication than the sequence of newly synthesized strand will be altered. As DNA polymerase III enzyme read thymidine dimers as single thymidine nucleotide and incorporate only 1 adenine in the newly synthesizing complementary strand which results in frame shift mutations

It is the mutation in which reading frame of codons is shifted or altered due to deletion or addition of a single nucleotide.

7 0
3 years ago
Put the last 6 (Creep to Avalanche) in order from Fastest to Slowest.
kompoz [17]

Answer:

creep, solifluction, slump, earthflow, mudflow, debris avalanche, rockfall

Explanation:

Mass movement also known mass wasting is the motion of rock,  regolith (loose mixture of soil and rock particles that covers the earth's surface), snow, and ice down a slope. Based on increasing speed of movement, the given mass movement processes are as follows:

Creep- this a very slow, usually continuous movement of regolith down slope.

Solifluction - this is a sediment flow. A sediment flow is a mixture of rock, regolith with some water. The rate solifluction is measured in centimeters per year. It occurs at a faster rate than than creep.

Slumps - is a type of mass movement whereby there is a downward rotation of rock or regolith along a curved surface producing depressions or scars on the slope. It occurs at a faster rate than solifluction.

Earthflows - they usually occur with heavy rains and occur at a much faster rate with velocities between several centimeters per year and hundreds of meters per day.

Mudflows- are a highly fluid mixture of sediment and water which usually result from heavy rains in areas where there is an abundance of loose sediment. These sediments are picked up by flowing streams of water. Mudflows occur at high velocities and can travel long distances.

Debris Avalanches - These are very high velocity mass movements that result from the complete collapse of a mountainous slope. Earthquakes and volcanic eruptions usually cause debris avalanches. Avalanches involving snow only is known as snow avalanches.

Rock Falls - Rock falls occur when a piece of rock which may be large or small on a steep slope comes loose and falls down the slope. On its way down it may dislodge other rocks which also fall down the slope. Rock falls are the fastest of the six types of mass movements stated.

7 0
3 years ago
Prevailing winds cause ocean currents to move in the same direction as the winds
Anarel [89]

Answer:

claim 1

Explanation:

this just has to do with simple energy and momentum conservation as the energy from the wind creates oceanic currents that move in the same direction of the current

Newton's first law of motion

this applies in all places in the ocean

6 0
3 years ago
Using specific examples, discuss the roles of negative and positive feedback processes that maintain homeostasis.
jek_recluse [69]

Answer:

Homeostasis typically involves negative feedback loops that counteract changes of various properties from their target values, known as set points. In contrast to negative feedback loops, positive feedback loops amplify their initiating stimuli, in other words, they move the system away from its starting state.

3 0
3 years ago
The graphic shows two isomers of a chemical compound with molecular formula C %H ! !NO @. Which type of isomers are these?
azamat
<span>C5H12 has only 3 isomers. They are pentane, butane and propane.</span>
5 0
3 years ago
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