The SH3 (SRC homology 3 ) domain in Src involved in various functions as regulation of cell cycle activities ( like cell proliferation and differentiation , survival ,migration and cytoskeletal modifications ) but Tyr 416 does not .
Hence the deletion or inactivation of the SH3 domain in Src would have an oncogenic effect while the mutation of Tyr 416 to phe would not.
<h3>What is SH3 domain ?</h3>
SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids .it is a small protein domain of about 60 amino acid residues .
<h3>What is oncogenic effect ?</h3>
If through mutation ,normal genes are up-regulated ( gain -of-function mutation ) ,they will predispose the cell to cancer ;these type of genes are called as oncogenes and their effect is called as oncogenic effect.
usually multiple oncogenes ,along with mutated apoptotic or tumor suppressor genes will all act in concert to cause cancer .
Learn more about cancer here:
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