Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Consider these three things:
Acute care hospitals play a significant role in geriatric care.
Older adults have higher rates of hospitalization compared with other age groups.
Older adults have a longer length of hospital stay compared with other age groups.
Answer:That substances give when dissolved in water are called electrolytes.
Explanation:Substances give when dissolved and divided into acids,salts and they are dissolved in water.
Electrolytes are the dissolved the combination blood and the coordinates all the functions.
Electrolytes are the balance is crucial to the many functions of bloods.
Electrolytes and decreased plasma and magnesium can muscle spasms the extremities.
Answer:
Patient identifier options include:
Name.
Assigned identification number (e.g., medical record number)
Date of birth.
Phone number.
Social security number.
Address.
Photo.
Explanation:
There are many Nurses or Doctors who gets confused about their patients name. Which i think is very unprofessional because you should always know you patient name you may give the the wrong treatment...thinking you already know them. Iv'e had this happen to me and felt happy to answer you question.
The answer to this would be. Depression!!!
