Question

What do you think would happen to urine volume if you did not add adh to the collecting duct?

Answer 1

The urine volume would increase if ADH was not added to the collecting duct.

What effect did the addition of ADH have on urine volume?

• Your response: ADH has the greatest influence on urine volume. When ADH was added, the urine volume decreased dramatically from 201 ml to 16 ml from the baseline value. This is due to ADH increasing the amount of water reabsorbed in the distal tubule, resulting in a decrease in urine volume.

• ADH increases the permeability of the distal convoluted tubule and collecting duct to water, which are normally impermeable. This effect increases water reabsorption and retention while decreasing urine volume relative to ion content.

• Antidiuretic hormone binds to receptors on cells in the kidney's collecting ducts and promotes water reabsorption back into the circulation. In the absence of antidiuretic hormone, the collecting ducts are nearly impermeable to water, which drains as urine.

• Diabetes insipidus is caused by a lack of ADH, also known as vasopressin (VP). Polyuria, dehydration, and thirst are the clinical signs. This condition usually develops because the pituitary gland's posterior lobe no longer produces enough ADH.

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