Ophelia listens to her kinsmen's advice and withdraws from him. Her withdrawal provokes an intense, misogynistic reaction from Hamlet, and ultimately Ophelia goes mad and dies tragically without the misunderstanding coming to light.
He is going on to insult Ophelia and tells her to visit a nunnery. He tells her that this can be a first-class place for her and, by means of being a nun, Ophelia may not have children and convey depraved men like his uncle.
Hamlet is merciless to Ophelia because he has transferred his anger at Gertrude's marriage to Claudius onto Ophelia. In fact, Hamlet's phrases suggest that he transfers his rage and disgust for his mother onto all women.
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