The Parasympathomimetic<u> </u>branch of the autonomic nervous system is activated by the family of pharmacological drugs known as parasympathomimetics. Agonists are two types of medicines.
The main neurotransmitter of the parasympathetic nervous system, acetylcholine (ACh), is mimicked or modified by parasympathomimetic medications to have their desired effects. Depending on whether they are direct or indirect agonists of acetylcholine ACh, parasympathomimetic drugs fall into one of two basic types. While indirect agonists raise synaptic levels of Acetylcholine ACh by decreasing the enzyme acetylcholinesterase, direct agonists directly bind and activate muscarinic ACh receptors.
Providers of healthcare should keep an eye on patients receiving parasympathomimetic drugs to make sure the treatment has the desired therapeutic impact. Parasympathetic Patients must be continuously monitored by the provider for any potential side effects. Due to the overstimulation of acetylcholine receptors, an overdose may cause a potentially fatal cholinergic crisis. There are several different formulations of parasympathomimetic drugs available to treat acetylcholine. To cure glaucoma and induce miosis during surgical operations, for instance, topical formulations of carbachol and pilocarpine are available for ocular use. Neostigmine is administered parenterally to treat paralytic ileus and act as a bladder agonist.
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