Question

Question 4 (1 point) Why are nonsense mutations rare?

Answer 1

When a DNA sequence alteration results in a stop codon rather than a codon that specifies an amino acid, it is known as a nonsense mutation. This is rarely seen in 10% of patients with genetic disease.

What is nonsense mutation?

A nonsense mutation in a DNA sequence causes a premature stop codon, also known as a nonsense codon, in the transcribed mRNA as well as a shortened, ineffective, and typically nonfunctional protein product.

Because stop codons, also known as nonsense codons, signal the completion of protein synthesis rather than encoding for an amino acid, they are the source of the term "nonsense mutation."

Examples of illnesses for which nonsense mutations have been implicated as contributing factors include: Cystic fibrosis (produced by the G542X mutation in the cystic fibrosis transmembrane conductance regulator); (CFTR) Beta-globin (thalassemia) Hurler disease.

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