Question

Examine a two-gene cross in which a mutation in herc2 is epistatic to the oca2 gene. In a cross between a blue-eyed oohh woman and a blue-eyed oohh man, what eye color will the progeny have?.

Answer 1

In a cross between a blue-eyed oohh woman and a blue-eyed oohh man, what eye color will the progeny have blue eye color.

• According to research on the genetics of eye color, blue eyes are caused by a mutation in the neighboring, unrelated gene HERC2.
• The gene OCA2, which controls the production of the brown pigment melanin, is silenced by this mutation. Today, between 20 and 40 percent of Europeans have blue eyes.
• The quantity of functional P protein that is generated is decreased by a number of frequent changes (polymorphisms) in the OCA2 gene.
• People with a variation in this gene have blue eyes instead of brown because less P protein implies less melanin is present in the iris.
• A disturbance in the normal generation of melanin brought on by OCA2 gene mutations results in visual issues and a loss of hair, skin, and eye color. Oculocutaneous albinism type 2 refers to oculocutaneous albinism brought on by mutations in the OCA2 gene.

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