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AURORKA [14]
1 year ago
7

Hepatocyte growth factor aff ects satellite cell activation and diff erentiation in regenerating skeletal muscle

Biology
1 answer:
vichka [17]1 year ago
4 0

Hepatocyte growth factor (HGF) is the only known growth factor that activates quiescent satellite cells in skeletal muscle.

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin.

HGF, produced by some cancer cells, stimulates c-Met, through activation of the autocrine signaling system. Hepatocyte growth factor (HGF) is a paracrine hormone that plays an important role in epithelial-mesenchymal transition. HGF secreted by mesenchymal cells affects many properties of epithelial cells, such as proliferation, motility, and morphology.

To learn more about Hepatocyte growth factor , here

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