Haploid refers to a cell that has has only one copy of each chromosome, like in a gamete such as a sperm cell or egg cell. Upon fertilization, the two haploids come together to form a full diploid cell (two copies of each chromosome) which then goes on to form the complete organism. Monosomy refers to a condition where there is only one copy of a specific chromosome. For example, in the human condition Turner Syndrome, there is only one X chromosome, instead of two sex chromosomes. Most incidences of monosomy other than Turner Syndrome are lethal, so there aren't many examples of it.
Answer:
The correct answer is "5-1-3-2-4".
Explanation:
Internalization of LDL particles into cells, is needed to form the intracellular vesicles known as endosomes. The order of events that allow for this process are:
5) LDL receptors migrate to the cell surface and cluster in clathrin-coated pits. Clathrin acts directing the receptors to the cell membrane region where endosomes are formed.
1) A combination of cholesterol and apolipoprotein binds to LDL receptors and becomes internalized as endocytotic vesicles. Once the receptors are in the proper cell membrane region, cholesterol and apolipoprotein are bound and internalized.
3) Several endocytotic vesicles fuse to form an endosome.
2) The environment of the endosome becomes acidic, which causes the LDL to dissociate from its receptor; additionally, the endosome fuses with a lysosome. LDL should be dissociated from its receptor since it is going to be degraded in the following step.
4) The LDL particle is degraded by the lysosome. This takes place after endocytosis, when LDL particles are transported into lysosomes once they are fused, cleaving the cholesterol esters into cholesterol and fatty acids.
