Secondary immunodeficiency is a deficiency or defect in body's immune system. 10 common diseases that can cause a secondary immunodeficiency are: leukemia diabetes skin cell diseases burns virus infection lymphoid malignancy nephrotic syndrome neutropenia human immunodeficiency virus protein-calorie malnutrition There is no known way to prevent inherited immunodeficiency disorders. but there is some ways to prevent infection like get enough sleep, keep clean, manage stress, eat right etc.