<span>When you are on
standby and it happens that a nearby infant suddenly begins to cough, you need
to give your attention to the infant just to check the infants’ condition. If
you have the medical knowledge, you can assess the infant by checking if there
is an obstruction to his/her mouth and if it is conscious. Then, you can give
sets of 5 back slaps and 5 chest thrusts to remove the object.</span>
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer:
The <u>nuclear envelope</u> is composed of two concentric lipid bilayer membranes separated by an intermembrane space of about 20-40 nm. The outer membrane is continuous in many places with the rough endoplasmic reticulum. Like the rough ER the outer membrane of the nuclear envelope is dotted with ribosomes.
