Answer: change the shape of the active site of an enzyme
Explanation:
Enzymes are also sensitive to pH . Changing the pH of its surroundings will also change the shape of the active site of an enzyme. ... This contributes to the folding of the enzyme molecule, its shape, and the shape of the active site. Changing the pH will affect the charges on the amino acid molecules.
I think it's surface area would be less than it's volume so it means it won't be able to get nutrition as needed.
hope this helps :P