C) Renal pelvis is the part of the kidney that acts as a funnel to pass the urine that is produced in several nephrons to the ureters.
It can't be released by photosynthesis
Answer: Combining a basic API with citric acid to produce the citrate salt of the API.
Explanation:
Chemical modifications refers to the processes that involve changes in the general composition of drugs to produce another entity with different chemical properties.
From the answer, Basic API combine with citric acid to produce the citrate salt of API which have different chemical properties from the reactants.
Answer:
1. interphase is the portion of the cell cycle that is not accompanied by gross changes under the microscope while phases is a distinct period or stage in a series of events or a process of change our development.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
