The main way in which the nature of European exploration changed by the seventeenth century was that by this time, the major European powers such as Spain and Portugal had claimed large amounts of territory in the New World, and already exporting large amounts of natural resources back to their homeland.
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The conflict between Henry IV and Gregory VII Concerned the question of who got to appoint local church officials. Henry believe that, asking, he has the right to a point the bishop of the German church. This was known as lag investiture.
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The Anti-Federalists argued that the Constitution gave too much power to the federal government, and less power to the states.
This would make the answer “the Constitution would make states less powerful”