I would say a because he ran too much but that would be just me I think he hurt his knee from running too much more exercise but probably just aggravate his condition I could be wrong but this is what I think
I believe the answer is the systemic circuit
sepsis is the result of an infection, symptoms can include infection signs (diarrhea, vomiting, sore throat, etc.), as well as ANY of the symptoms below:
Shivering, fever, or very cold
Extreme pain or discomfort
Clammy or sweaty skin
Confusion or disorientation
Short of breath
High heart rate
ADD
OCD
Insomnia
Schizophrenia
Sensory anxiety
Social anxiety
Asthma
Dyslexia
Dyscalculia
Common cold
Flue
(Dude, there is a lot of health challenges mental and physical.)