Many of the members of De Soto's expedition were carriers of diseases such as measles, smallpox, and chicken pox. Very few of American Indian have resistance to the disease because they never exist near their environment before.
As a result, the Infections ran rampant in the American Indian's community.
Since they did not have a medical knowledge to deal with it, the contagion resulted in a lot of deaths. Massively decreased American Indian's population.
He was a great face for NASA, and was seen as a family man. The biggest achievement causing him to be positive for NASA was being the first American to be in orbit.