Properties of metals are traits displayed by most metals.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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If you’re trying to figure out if it’s true or false it’s true
Answer:
C. Diploid condition
Explanation:
A Karyotype is the pictorial display that shows chromosome arrangement and number in a cell. The Karyotype shows any abnormalities in the nuclear material (chromosomes). In a carrot plant that was cloned from carrot root, the clones should possess the same features as the original plant.
A Karyotype of both plants i.e. clone and the original plant should show that their cells have a diploid number of chromosomes i.e. Two sets of chromosomes. Since a carrot plant is a diploid organism.
