The Columbian Exchange greatly affected almost every society on earth, bringing destructive diseases that depopulated many cultures, and also circulating a wide variety of new crops and livestock that, in the long term, increased rather than diminished the world human population:)
Populism rise to promote democratization and to have a government for the people. In Brazil, populism was used by their President Getulio Vargas to be in his place. In Argentina, the government used populism to increase wages but resulted in inflation because of instability to sustain economic reforms to people.
An extremely hostile relationship characterized by slaughter, competition, and greed.
European powers were running out of places to colonize in africa, while trade in East Asia was becoming more and more profitable, but the cost in time and money of traveling all the way around africa and through the india ocean (or the long trek down the silk road) was hampering European profits off of trading. So the Spanish sent Columbus to find a shorter root to Asia. Columbus didn't set out looking for America, it was just a happy accident.