Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Históricamente, las mujeres han constituido una gran mayoría de la profesión y disciplina académica de la enfermería.
Explanation:
Los roles de enfermería de las mujeres incluyen tanto cuidar a los pacientes como asegurarse de que las salas y el equipo estén limpios. Actualmente, las mujeres constituyen la mayor parte del campo de la enfermería.
Espero que esto te ayude :)
Answer:
nerves guarantees that each hemisphere receives binocular input from the contralateral visual hemifield
Explanation:
Answer:
A. Hair on the scalp
Explanation:
Please correct me if I am wrong :)
Well in the question it talked about head so of course the hair on the scalp.
Answer:
d is correct am pretty sure
Explanation:
hope it helps