The explorations of the European nations were triggered mainly by the capturing of Constantinople by the Ottomans and that the waters in the eastern part of the Mediterranean became very unsafe for trade and travel, and they needed badly this routes for trade with Asia. So the European nations decided to find other routs towards Asia which will be better options for them, but instead of finding new roots to Asia, they found two new continents, North and South America.
The Europeans that managed to make colonies in the Americas gained new territories, lots of natural resources, discovered new plants, and that was very profitable for the colonial countries.
The Native Americans, on the other hand, were faced with a big threat, and they lost their territories, lots of them also lost their lives, were treated very badly and brutally in general, and ended up as second class people in the newly formed societies.