That is the difference between the two, I am not good at explaining these types of things! XD
<span>I have to talk to you. I appreciate your humor but lately you've really been putting me down in front of my friends, and it's been bothering me. I know you don't mean it, but you've been hurting my feelings and making me feel insignificant in front of my friends. Do you think you can try not to do that anymore?</span>
Answer: Public health measures such as pure food and water, and development of immunizations against many serious diseases such as polio and smallpox, coupled with enhanced economic conditions, are together credited with substantial reductions in the burden of infectious diseases.