Answer:
The binding of ACh to the muscarinic receptor indirectly affects the permeability of K⁺channels. This can produce hyper polarization in some organs if channels are opened, and depolarization in others if channels are closed.
Explanation:
For example, in the heart it is the beta-gamma compound that fixes to the K+ channels of heart muscle and sources them to exposed. This leads to K+ dispersion out of the cell and the cell converts into hyper polarized consequential in a reduction in heart rate. In contrast, in smooth muscle of the stomach the alpha sub unit fixes to K+ channels producing them to close. This decreases the external diffusion of K+ and the cell converts depolarized ensuing in smooth muscle contraction.
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