Ras is a GTP-binding protein involved in cell proliferation (division). In its active form, with GTP bound, Ras activates cell s
ignaling pathways that promote cell division. Mutations in the gene that encodes Ras can lead to cancer. How might mutations in the gene encoding Ras lead to the uncontrolled proliferation characteristic of cancer cells
Mutations in the active site induce a continue 'switch-on state' of the Ras proteins
Explanation:
Ras is a family of GDP/GTP-binding proteins expressed in all animal cells. Ras proteins play roles in signal transduction pathways, where they are activated to subsequently 'switched on' other proteins involved in diverse cellular processes including cell growth, cell differentiation and survival. In consequence, the Ras genes are considered to be oncogenes because when they are overexpressed in cells their encoded proteins produce uncontrolled cell proliferation, thereby leading to cancer progression.
In a mammalian brain, there are four major lobes that are present and one of them is the frontal lobe.
The frontal lobe is mainly rich in dopaminergic neurons and thus, it is mainly concerned with functions such as memory, reward, motivation, planning, attention, etc.
The process of break down of tissues and cell death in the tissues is referred to as atrophy and since the frontal lobe is associated with the functions as mentioned above its atrophy would lead to a slow decline in these functions.
Since Mr. Klondlike behavior is changing his blunt comments are most likely a result of atrophy of the frontal lobe.
