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ss7ja [257]
4 years ago
10

Phase II drug degradation reactions involves linking of conjugates to the drugs are ___

Biology
1 answer:
Sergio [31]4 years ago
3 0

Answer:

Hi!

The answer is (C) Both (a) and (b)

Explanation:

Drug Metabolism:

  • Drug metabolism is divided into two steps: Phase 1 and Phase 2 reactions.
  • Phase 1 reactions involve the degradation or formation of functional groups.
  • Phase 2 reactions involve the conjugation of the drug or its Phase 1 intermediate with a polar conjugating molecule. Phase 2 generally performs the detoxification step in the drug degradation process.
  • Phase 2 or conjugation reactions are further divided into 2 types:
  • Type 1: Glucoronidation and sulfonation: An activated conjugating molecule such as glucoronic acid, sulfate or glutathione etc. is combined with the drug to form a conjugated molecule.
  • Type 2: Amino acid conjugation: An activated drug or substrate is conjugated with an amino acid such as glycine or glutamine.

Glutathione Conjugation:

Glutathione is a tripeptide found in most tissues, particularly in the liver. It performs important detoxification functions for all cells. The enzyme, glutathione S-transferase conjugates glutathione with drug intermediates to form a drug-glutathione conjugate. This conjugate can easily be excreted through bile or urine.

Amino acid Conjugation:

This is an important reaction in xenobiotic biotransformation; particularly for xenobiotics with carboxylic group or an aromatic hydroxylamine groups. Drug intermediates combine with glycine or glutamine to form an amino acid conjugate.

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Hope this helps... stay safe and have a great weekend!!! plz mark me brainliest if i am right!!!! :D

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