The Spanish conquistadors believed them to be infidels. They would read them a note from the Pope in Spanish that they wouldn't understand in which they would proclaim that their land would now be Spanish because Spain is governed by one true God, and after that they would slaughter them if they wouldn't surrender.
This impacted the power of the roman catholic church by calling the people to pray, aswell as organizing religious trecks and creating a petition to stop the pestilence
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