Question

Scientists develop knowledge by making about the natural world that may lead to a scientific question

Answer 1

Hypothesis? 
There's my educated guess  

Answer 2

Answer:

Scientists develop knowledge by making observations about the natural world that may lead to a scientific question

Explanation:

Science has been able to change history and develop some elemental theories that explain how everything works by following some steps. These steps are known as the "scientific method", which can be described as a systmatic way of learning about the world and answering questions. The most basic step that allow scientists to develop questions about something is the observation, by observing things doubts will emerge. This will lead to the next step that is asking questions. In this way your research problem will be more accurate and therefore easier to study. The following steps are: form an hypotesis, make a prediction based on the hypotesis and test the prediction.