Depression is the disorder where people spend most of their time sleeping.
Depending on the person, many different things could work like meditation, talking to friends, maybe having some tea, taking a shower, going for a drive, having some comfort food, and so many other things that allow you to release endorphins and relax your brain. : D
Neurotransmitters would continue to bind and rebind with the postsynaptic receptors, which would continue induction of a signal in the postsynaptic neurons, which would repropagate the initial signal.
The case in drugs that block reuptake transporters (such as in serotonin reuptake inhibitor and norepinephrine reuptake inhibitor antidepressants, and dopamine reuptake inhibition found with cocaine and methylphenidate).
My guess is let him freeze his butt off then have his coat waiting at the door when he realizes he was wrong. It's called letting him learn from experience.
