Yeah yeah so :D,
Large polar molecules can only cross the membrane with the help of protein named channel protein and carrier protein.
So, this both proteins act like a gate, the large molecules enter the protein and the protein let the large molecules in to the membrane. (see the picture so that you can understand more, its carrier protein)
the only difference between channel protein and carrier protein is, channel proteins has fixed shape while carrier protein can flip.
It uses its potential energy and converts it into kinetic energy as it falls (the lower it is during the fall it will be mostly kinetic, however the higher it is during the fall it will be mostly potential energy)
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Fire destroys the area but then New Life Springs back stronger From the Ashes people are interfering with the Prairie ecosystem by stopping the or preventing these hopeful fire
Answer:
DNA is duplicated, or copied
Explanation:
Hope this helps
