The
presence of osmotically active substances in urine will produce more urine for
the reabsorption of water is reduced relative to Na+. <span>This
active substances primarily
inhibit water reabsorption in the proximal convoluted tubule and the thin
descending loop of Henle and collecting duct and regions of the kidney that are
highly permeable to water. </span>
In
addition, it also extract water from intracellular
compartments that result to increase extracellular fluid volume or urine
output.
