I would go with Bubonic Plague.
Reasoning: While all of those answers had some result on economies, the bubonic plague (AKA Black Death) had the greatest economic effect. The more than 20 million that died across Asia and Europe produced a lack of workers that slashed economic growth while the laborers who still remained demanded higher wages due to the increase of work, causing continental economic havoc.
Answer:
I solved it. Use my attachment above ^^
· The twelve states that make up this Region are South Carolina, Virginia, West Virginia, North Carolina, Mississippi, Arkansas, Tennessee, Florida, Georgia, Alabama, Kentucky and Louisiana.
· Of the Southeast region states, Florida is the most populous with 19,552,860 (2013 U.S. Census Bureau) people and Jacksonville, Florida is the most populous city with 836,507 people (2012 U.S. Census Bureau).
· Being closer to the equator than the Northeast region, the climate in the Southeast tends to be very mild and humid with hot summers and short winters.
· Dixie is the nickname given to the Southeastern portion of the United States.
· Because many of the people in the southeast have values that are centered around religion and conservatism, much of the southeast region is informally known as the "Bible Belt".
· The southeast region is part of what is called the Sun Belt which stretches across the southern part of the U.S. and includes many types of climates from dessert to tropical. The southeast region is considered to be the humid subtropical portion.