The answer is (C) Replication
Though occasional errors could occur in cells during replication; the cells have error checking and proofing mechanisms that reduce the rate of error to one to several million replications in higher eukaryotes.
After all, one mismatch error during replication would not result in major effects. The others choices, however, have higher rates of causing genetic abnormalities.
The endocrine system is made of glands that secrete hormones. These hormones help regulate the organs and cells activity. The hormones among other things control your metabolism.