I think it is A but not 100% sure. Think of an enzyme like a key unlock the lock is the protein. And to activate getting inside your car or house you have to fit the key into the lock.
Answer: if change happens naturally in an ecosystem it will be better evolved to handle it. But at the expense it happens very slowly
Explanation: my answer
Answer:
Pesticide resistance at a population level, as opposed to just a few individual pests within a species, can occur after repeated exposure to a single type of pesticide. ... When a resistant population occurs, the pesticide is no longer useful for managing that specific pest and other management options must be sought out.