Much like signs and symbols, frames appear natural and go largely unquestioned.
Explanation;
Framing involves the presentation and communication of a message in a particular way that influences our perception of it; frames act like signs/symbols in semiotics (once accepted, they appear natural and go largely unquestioned); also shapes our perceptions of people, places, issues, and events; veteran's "rights" versus "benefits" provide an example of this.
The only way for a cell to use energy stored within a molecule is in this example would be to break the bond between 1 and two because it would be impossible for energy to get to 3, 4, 5.