What is one of the benefits of protecting patient rights?
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Option C - T cells (Tregs) stand for regulatory T cells
Recent systematic studies have shown that Treg levels are significantly decreased in peripheral blood and decidua of pregnant and non-pregnant women with recurrent miscarriages (RM).
This underlines the hypothesis that Tregs play a role in the pathogenesis of RM. To ensure a robust placenta and sustainable pregnancy, an active state of tolerance on the level of immunity by Tregs is essential.
Survival of the allogeneic embryo in the uterus depends on the maintenance of immune tolerance at the maternal-fetal interface. The pregnant uterus is replete with activated maternal immune cells. How this immune tolerance is acquired and maintained has been a topic of intense investigation. The key immune cells that predominantly populate the pregnant uterus are natural killer (NK) cells.
In normal pregnancy, these cells are not killers, but rather provide a microenvironment that is pregnancy compatible and supports healthy placentation. In placental mammals, an array of highly orchestrated immune elements to support successful pregnancy outcomes has been incorporated. This includes active cooperation between maternal immune cells, particularly NK cells, and trophoblast cells.
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