Respiratory system: smoking irritates the windpipe and voice box. The lung airways will also swell and narrow, and there will be excess mucus in the lung passages. It also affects the lung's clearance system, which may lead to toxic buildup.
Circulatory system: There will be raised heart rate and blood pressure. Blood will also become stickier and more prone to clotting. The lining of the arteries will also be damaged. Smoking will reduce blood flow to fingers and toes; will also constrict blood vessels in the skin.
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True. Explanation: entrainment of ventilation and locomotion
Pandemics are diseases that spread over large areas and affect large numbers of people. The Black Death in the 14th century killed nearly one quarter of Europe's population. The Spanish Flu, in 1918, killed more people than WWI.