Answer:
Symptoms
Signs and symptoms of hemophilia vary, depending on your level of clotting factors. If your clotting-factor level is mildly reduced, you may bleed only after surgery or trauma. If your deficiency is severe, you may experience spontaneous bleeding.
Signs and symptoms of spontaneous bleeding include:
- Unexplained and excessive bleeding from cuts or injuries, or after surgery or dental work
- Many large or deep bruises
- Unusual bleeding after vaccinations
- Pain, swelling or tightness in your joints
- Blood in your urine or stool
- Nosebleeds without a known cause
- In infants, unexplained irritability
Bleeding into the brain
A simple bump on the head can cause bleeding into the brain for some people who have severe hemophilia. This rarely happens, but it's one of the most serious complications that can occur. Signs and symptoms include:
- Painful, prolonged headache
- Repeated vomiting
- Sleepiness or lethargy
- Double vision
- Sudden weakness or clumsiness
- Convulsions or seizures
Causes
When you bleed, your body normally pools blood cells together to form a clot to stop the bleeding. The clotting process is encouraged by certain blood particles. Hemophilia occurs when you have a deficiency in one of these clotting factors.
There are several types of hemophilia, and most forms are inherited. However, about 30% of people with hemophilia have no family history of the disorder. In these people, an unexpected change occurs in one of the genes associated with hemophilia.
Acquired hemophilia is a rare variety of the condition that occurs when a person's immune system attacks clotting factors in the blood. It can be associated with:
- Pregnancy
- Autoimmune conditions
- Cancer
- Multiple sclerosis
Treatment
Several different types of clotting factors are associated with different varieties of hemophilia. The main treatment for severe hemophilia involves receiving replacement of the specific clotting factor that you need through a tube placed in a vein.
This replacement therapy can be given to combat a bleeding episode that's in progress. It can also be administered on a regular schedule at home to help prevent bleeding episodes. Some people receive continuous replacement therapy.
Replacement clotting factor can be made from donated blood. Similar products, called recombinant clotting factors, are manufactured in a laboratory and aren't made from human blood.
Other therapies may include:
- Desmopressin. In some forms of mild hemophilia, this hormone can stimulate your body to release more clotting factor. It can be injected slowly into a vein or provided as a nasal spray.
- Clot-preserving medications. These medications help prevent clots from breaking down.
- Fibrin sealants. These medications can be applied directly to wound sites to promote clotting and healing. Fibrin sealants are especially useful in dental therapy.
- Physical therapy. It can ease signs and symptoms if internal bleeding has damaged your joints. If internal bleeding has caused severe damage, you may need surgery.
- First aid for minor cuts. Using pressure and a bandage will generally take care of the bleeding. For small areas of bleeding beneath the skin, use an ice pack. Ice pops can be used to slow down minor bleeding in the mouth.
- Vaccinations. Although blood products are screened, it's still possible for people who rely on them to contract diseases. If you have hemophilia, consider receiving immunization against hepatitis A and B
<h2>
Biennial plants</h2>
Explanation:
This plant is a biennial, which means it will just take longer than a season to mature enough to produce flowers.
Since the Sweet William plant did not flower last year when it was planted and this year also it did not bud till the spring. So, we can assume that these plant will need atleast two seasons to mature hence they are biennials.
Depending on the life span, plants are classified as annuals (one season), biennials(two season) and perennials (more than two years).
Answer:
Generation of an action potential in the neuron.
Stimulation of Ca2+ entry into the neuron
Release of acetylcholine into the synapse
Depolarization of the muscle fiber membrane
Explanation:
The following events takes place in the vertebrate neuromuscular junction
a) Nerve Action Potential - Action potential reaches the axon terminal
b) Entry of calcium ion - The calcium ion reaches the axon terminal and enter into the presynaptic terminus after which the Synaptic vesicles fuse with the membrane of axon terminal
c) Releasing of Arch Quanta - Acetylcholine is released into synaptic cleft which then binds to the receptor sites on motor end plate
d) The Na+/K+ channels opens and Motor end plate becomes depolarized.
