The most important reason why Wilson’s opponents argued against the League of Nations was because <u>America wanted to have an isolationist policy. </u>
After World War I ended in 1918, America wanted to adopt an isolationist policy, that had been previously interrupted due to the war. The U.S. wanted to stay out of global affairs, avoid political or economic alliances that didn't serve their interests and focus on domestic issues instead. Entering the League of Nations, an organization for international cooperation, would mean to be part of international issues, make alliance and defend other nations if it was necessary, among others.
The documented that upheld George Washington's policy of the United States not getting entangled in internal European Affairs and existing European Colonies for many years was Known as the Monroe Doctrine. The intent and impact of the Monroe Doctrine was to speerate the spheres of influences between the old world (Europe) and the New world ( America).