Answer: 2. Low-dose colchicine
Explanation:
Colchicine is a drug which is used to prevent the attacks of the gout. The gout is caused due to the presence of too much uric acid in the blood. The gout attack occurs when uric acid in the blood causes the inflammation involving the pain, heat, irritation, swelling in the joint.
The use of low-dose regularly of colchicine is useful for preventing the attacks of gout and the effect remains for long time in the body.
The (key)substrate fits into the active site of the (lock)enzyme.
Loneliness and social isolation have been linked with premature mortality and with functional decline in older people.
We found that high levels of loneliness, but not of social isolation, increased the risk of becoming physically frail.
Neither loneliness nor social isolation were associated with the rate of change in a more broadly defined frailty index.
Loneliness
Loneliness is a subjective feeling of dissatisfaction with one’s social relationships. Both social isolation and loneliness have been linked with increased mortality [2–4], incident heart disease [5, 6] and functional decline [7, 8]. Social isolation and loneliness tend to be correlated, albeit weakly .
Social isolation :
Social relationships are important for health . Most such research has focused on social isolation or loneliness. Social isolation is defined objectively using criteria such as having few contacts, little involvement in social activities and living alone.
Frailty :
Frailty is a clinical syndrome whose main feature is heightened vulnerability to stressors due to lowered physiological reserves, decline in the ability to maintain homeostasis and impairments in multiple systems
A frailty index score reflects the proportion of potential deficits present The phenotype model defines frailty in physical terms, whereas the cumulative deficit model uses a broader definition of frailty.
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Answer:
legislative advocacy -
Explanation:
legislative advocacy -
It is defined as discussions which are based on modification of any bill.
It is assurance given to particular set of groups about their rights by making discussion with policy maker and legislator. The simple way to legislative advocacy is to contact with policy maker involves in particular bill by requesting them to vote for specific bill.
Nowhere was that diversity more evident in pre-Revolutionary America than in the middle colonies
