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FromTheMoon [43]
3 years ago
13

4. Juan’s family has a history of sickle cell disease. His father died of sickle cell disease complications when Juan was six ye

ars old. He remembers his father being in great pain. Juan marries Gina. Gina’s maternal grandmother and paternal grandfather had sickle cell disease, but neither of her parents has the disease. Juan does not want to have children because he is convinced they will have sickle cell disease. Gina is not so sure. They have come to you for advice about having whether or not to have children. Based on your calculations of the probability of their child getting sickle cell disease, what is your advice? Show your calculations and explain your reasoning for your response. It may be helpful for you to draw pedigrees and possible Punnett squares for both Juan’s and Gina’s families.
Biology
1 answer:
r-ruslan [8.4K]3 years ago
5 0
Sounds like juan has a hard life. LOL CYANIDE CAPSULES?
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A) In the Dunker population, the frequency of IB allele is 0.3 and the frequency of i allele is 0.4. In the general population, the frequency of IB allele is 0.1 and t<span>he frequency of i allele is 0.5.
</span>
If:
I^{A} - <span>the frequency of IA allele
</span>I^{B} - <span>the frequency of IB allele
</span>i - t<span>he frequency of i allele

Then:
</span>I^{A} I^{A} + <span>I^{A} i - the frequency of individuals with A blood type
</span>I^{B} I^{B} + <span>I^{B} i - the frequency of individuals with B blood type
</span>ii <span>- the frequency of individuals with O blood type
</span>
Let's first take a look on the Dunker population:
I^{A} = 0.3
ii=0.16&#10;

<span>Since there is only one possible genotype for O individuals - ii - the frequency of the allele i is square root of the frequency of O individuals:
</span>i= \sqrt{ii}
⇒ i =  \sqrt{0.16}
⇒ i=0.4

Now, we have the frequencies of two alleles (I^{A} and i). To calculate the frequency of I^{B}<span> allele, we will use the formula:
</span>I^{A} + I^{B} + i = 1
⇒ I^{B} = 1- I^{A} - i
⇒ I^{B} = 1-0.3-0.4
⇒ I^{B} = 0.3

Now, in the general population:
I^{A} = 0.4
ii=0.25

<span>Similarly to the work for the Dunker population:
</span>i= \sqrt{ii}
⇒ i = \sqrt{0.25}
⇒ i=0.5

I^{A} + I^{B} + i = 1
⇒ I^{B} = 1- I^{A} - i
⇒ I^{B} = 1-0.4-0.5
<span>⇒ I^{B} = 0.1
</span>


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