The sealing of nicks between two adjacent residues of a single-strand(ss) break on a double-strand DNA and the joining of double-strand breaks.
This is enzymatically catalyzed by the enzyme DNA ligase.
DNA ligation is the joining ends of 2 DNA molecules by the enzyme, DNA ligase. DNA ligase catalyzes the formation of two covalent phosphodiester bonds between the 3' hydroxyl group of one nucleotides and the 5' phosphate group of another and it is an ATP dependent reaction.
DNA Ligation occur most efficiently between those DNA fragments that have complementary sticky ends.
