Question

When actively growing cells are treated with taxol, they often are unable to complete the cell cycle. based on what you have learned about cell-cycle checkpoints, which checkpoint likely causes these cells to arrest? explain your reasoning?

Answer 1

Taxol block the depolymerization of the microtubule that occurs during the anaphase of M phase in which the chromosomes are pulled towards opposite pole. Due to lack of pulling, separation of the chromosomes is not possible. Hence the cells will be arrested at M phase checkpoint