Single Recognition Particle (SRP) RNA is necessary for the targeting of proteins to the prokaryotic plasma membrane or to the eukaryotic endoplasmic reticulum membrane. Its job is to bind to the signal peptide of the membrane or secretory proteins coming from the ribosome at which time it forms a ribosome-nascent chain (RNC)-SRP complex.
SRP plays an important role in understsnding bacterial physiology, emphasizing the importance of proper membrane protein biogenesis, and demonstrates the ability of time-resolved quantitative proteomic analysis to provide new biological insights.
