Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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The use of vaginal inserts of Lactobacillus to restore a healthy acidic environment is an example of probiotics.
<h3>What are probiotics?</h3>
Probiotic consumption is the intentional consumption of microorganisms that are considered "good" for the body and relatively safe to ingest. This is often done in an attempt to restore a healthy balance of microflora in distinct parts of the body, such as the one mentioned in this question.
Therefore, we can confirm that because this includes the intentional incorporation of bacteria with the end goal of restoring a healthy environment in the body, it can be considered an example of probiotics.
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Miss Philadelphia. The part of the root that contains transport tubes is the root hair. The primary role of the root hair is to absorb water and nutrients from the soil.
Answer:
Pyruvate kinase is the important enzyme that catalyzes the conversion of phosphoenol pyruvate into the pyruvate in the glycolysis cycle. This step generates the ATP molecule.
The regulation of the pyruvate kinase is done by the allosteric regulation and fructose 1,6 biphosphate activates the pyruvate kinase. This regulation is important as it control the metabolites present in different organs. The metabolites like fructose, galactose enters in the glycolysis from the liver after the particlar step of glycolysis.