Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The strategies for preserving, or treating the dead body, that the old Egyptians utilized is called Mummification. Utilizing exceptional procedures, the Egyptians expelled all dampness from the body, leaving just a dried shape that would not effortlessly rot. Mummification was polished all through the vast majority of early Egyptian history.
Answer:
Elastomeric
Explanation:
An elastomer is a polymer whose main characteristic is elasticity and can even recover its shape after being deformed
The chemical composition of an elastomer is the grouping of thousands of molecules called monomers, which join together forming huge chains. These large chains of polymers are those that give elasticity since they are flexible and are intertwined in a very messy way.
When an elastomer is stretched, its molecules align, allowing many times to take a crystalline appearance. However, upon releasing the tension, it immediately returns to its original state of elastic disorder. The above distinguishes elastomers from plastic polymers.
Hi the rectal route is preferred over the oral route because- rectal medications are usually not subject to first pass metabolism.
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Answer:
Primers should be:
3 'ACGTATGTCGCTTAGT 5'
5 'ACGTTCCAGTCAATGA 3'
Explanation:
DNA replication occurs with the need for the presence of primers that are a small sequence of nitrogenous bases that will allow the initiation of replication.
Primers are extremely important in PCR and are represented as small pieces of single-stranded DNA that specify the region of DNA that should be replicated during PCR. These primers attach to the single strand of DNA by pairing the nitrogenous bases allowing the DNA polymerase to recognize where replication begins.
Regarding the question above, the primers should be:
3 'ACGTATGTCGCTTAGT 5'
5 'ACGTTCCAGTCAATGA 3'
