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Alexander's death was sudden and his empire disintegrated into a 40-year period of war and chaos in 321 BCE. The Hellenistic world eventually settled into four stable power blocks: the Ptolemaic Kingdom of Egypt, the Seleucid Empire in the east, the Kingdom of Pergamon in Asia Minor, and Macedon.
After the death of Alexander the Great in 323 B.C., anti-Macedonian sentiment again forced Aristotle to flee Athens. He died a little north of the city in 322, of a digestive complaint. He asked to be buried next to his wife, who had died some years before.
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The Himalayas were harsh, and hard to pass through. The climates were cruel and cold. Although, Hindu Kush was easier to pass through and typically had fair climate.
