When exposed to smoke, hydrogen cyanide may play a role in rendering firemen and bystanders incapable of performing self-rescue.
HCN is a toxin that spreads throughout the body; it is hazardous because it inhibits cytochrome oxidase, which stops cells from using oxygen. Loss of awareness, respiratory arrest, and finally death arise from inhibition of the last stage of electron transport in brain cells.
Higher HCN exposures cause cardiovascular collapse, tremors, cardiac arrhythmia (which may not manifest for two to three weeks after the fire exposure), coma, respiratory depression, and respiratory arrest. Inhaling minute concentrations of hydrogen cyanide can result in headaches, weakness, nausea, and vomiting. Larger doses might result in fainting, convulsions, gasping, fast pulse, irregular heartbeat, and even death. In general, the severity of the symptoms increases with the seriousness of the exposure.
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Trade was also a boon for human interaction, bringing cross-cultural contact to a whole new level. When people first settled down into larger towns in Mesopotamia and Egypt, self-sufficiency – the idea that you had to produce absolutely everything that you wanted or needed – started to fade. A farmer could now trade grain for meat, or milk for a pot, at the local market, which was seldom too far away. Cities started to work the same way, realizing that they could acquire goods they didn't have at hand from other cities far away, where the climate and natural resources produced different things. This longer-distance trade was slow and often dangerous but was lucrative for the middlemen willing to make the journey. The first long-distance trade occurred between Mesopotamia and the Indus Valley in Pakistan around 3000 BC, historians believe. Long-distance trade in these early times was limited almost exclusively to luxury goods like spices, textiles, and precious metals. Cities that were rich in these commodities became financially rich, too, satiating the appetites of other surrounding regions for jewelry, fancy robes, and imported delicacies. It wasn't long after that trade networks crisscrossed the entire Eurasian continent, inextricably linking cultures for the first time in history. By the second millennium BC, former backwater island Cyprus had become a major Mediterranean player by ferrying its vast copper resources to the Near East and Egypt, regions wealthy due to their own natural resources such as papyrus and wool. Phoenicia, famous for its seafaring expertise, hawked its valuable cedarwood and linens dyes all over the Mediterranean. China prospered by trading jade, spices, and later, silk. Britain shared its abundance of tin.
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Federalism in Nepal: Issues and Challenges ... concentration of power and opposed to every effort of the devolution of power. ... A country may have federal ... autonomous regions and districts elected by the people in order to strengthen.
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