The correct option is D) Advanced weapons.
Though the Aztecs held the most powerful empire in Central America, the Spanish had an advantage of Advanced Weapons that contributed to the Aztecs' defeat.
Before the arrival of the Spanish, the Aztec Empire was the dominant economic and political force in South America.
The Empire has a complex government system, a sophisticated economy and a well developed social structure.
Many of the Aztecs were well-versed in developing large buildings, architecture, in agriculture, sports, mining and even astronomy. However, the technologically they were still far behind the Europeans.
Their limited weaponry was no match for the muskets of the time. We should also not forget that even a larger part of the population died due to the diseases brought on from the old world.
The local population had no immunity towards measles, small pox and other contagious diseases.