The alteration in the protein structures can take place due to many reason. Once, the structure of the protein is altered, it cannot perform its function, as it cannot bind to the site for which it is designated.
Most of the biological processes use proteins in their completion. In case, the protein cannot perform its function, the metabolic process associated with that particular protein may stop and cause severe illness.
The heat can cause the denaturation of the proteins. The proteins are made up of amino acid sequences, the heat can break the peptide bond present between the amino acids present in protein, which can result in alteration of protein.
Hence, the correct answer is option (d). all of them are correct.